Structure of PDB 6l54 Chain C

Receptor sequence
>6l54C (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
AKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKS
MVMSLLSANTPEEDQRTYVFRAQSAEMKERGGNQTSGIDFFITQERIVFL
DTQPILSPSILDHLINNPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQD
WFTDLSLYRFLQTAEMVKPSTPTEYYPHLVFLQNKARREDFCPRKLRQMH
LMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDSEVNLPLFSLLPGYR
GHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVRKSSA
LAEYSRLL
3D structure
PDB6l54 Cryo-EM structure of SMG1-SMG8-SMG9 complex.
ChainC
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP C Q213 G216 K217 S218 M219 A240 Q241 M245 P272 N372 K373 L428 Q45 G48 K49 S50 M51 A72 Q73 M77 P104 N184 K185 L240
BS02 MG C S218 T253 S50 T85
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0007420 brain development
GO:0007507 heart development
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6l54, PDBe:6l54, PDBj:6l54
PDBsum6l54
PubMed31729466
UniProtQ9H0W8|SMG9_HUMAN Nonsense-mediated mRNA decay factor SMG9 (Gene Name=SMG9)

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