Structure of PDB 6l2c Chain C

Receptor sequence
>6l2cC (length=398) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
EIQEAYILSGARTPTAKFNGSFVSVSAPELGAVAIKSAVSKSGVPVEKIT
DVYMGNVLQGAVGQAPARQASMFAGLSPTVESMTVNKVCASGLKAVALAA
QNIQLGLAEAQVAGGMENMSRVPYYLPRSTQLPPFGEIKLQDGLIQDGLW
DVYNQFHMGICAEKTAKKYEISREEQDQYAIQSYQRAQAAWKENKFAEEI
APVTVKGKKGETVVERDEGYENLRIDKMATLKPAFLRDGTGTVTAGNAST
MNDGASALVLGSKAIAREFAQGNRALARIVSTADAAIDPVDFPVAPAKAV
PIALERAGITKDQVAVWEFNEAFAAVIKANEKILGLQNARVNPLGGAISL
GHALGSSGSRILVTLLHQLQPGEYGVAAICNGGGAATAMVVQKLDRVD
3D structure
PDB6l2c Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
ChainC
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C124 H387 C415 G417
Catalytic site (residue number reindexed from 1) C89 H352 C380 G382
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA C C124 L184 M193 Y219 N257 R259 M263 L266 A280 S284 T285 F358 C89 L149 M158 Y184 N222 R224 M228 L231 A245 S249 T250 F323
Gene Ontology
Molecular Function
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6l2c, PDBe:6l2c, PDBj:6l2c
PDBsum6l2c
PubMed32005728
UniProtB0XMC1|ER10A_ASPFC Acetyl-CoA acetyltransferase erg10A, mitochondrial (Gene Name=erg10A)

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