Structure of PDB 6kc6 Chain C

Receptor sequence
>6kc6C (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNC
RVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGGGCRVI
EQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYE
VEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRR
3D structure
PDB6kc6 Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
ChainC
Resolution2.123 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C871 C874 C890 C893 C5 C8 C24 C27
BS02 ZN C C898 C901 H926 C930 C32 C35 H60 C64
BS03 ZN C C911 C916 H923 H925 C45 C50 H57 H59
BS04 ZN C C969 C986 C998 H1001 C97 C114 C126 H129
BS05 D60 C G884 C885 M886 H887 F905 L922 R935 G18 C19 M20 H21 F39 L56 R69
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6kc6, PDBe:6kc6, PDBj:6kc6
PDBsum6kc6
PubMed32246052
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

[Back to BioLiP]