Structure of PDB 6kc4 Chain C

Receptor sequence
>6kc4C (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
KPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQR
RHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPK
3D structure
PDB6kc4 High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase.
ChainC
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Y509 N512 Y57 N60
BS02 peptide C R467 R483 S485 H486 G487 V493 R503 H504 F505 I506 F516 E517 R15 R31 S33 H34 G35 V41 R51 H52 F53 I54 F64 E65
External links
PDB RCSB:6kc4, PDBe:6kc4, PDBj:6kc4
PDBsum6kc4
PubMed31441171
UniProtP16591|FER_HUMAN Tyrosine-protein kinase Fer (Gene Name=FER)

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