Structure of PDB 6k7i Chain C

Receptor sequence
>6k7iC (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
PDNTAFKQQRLPAWQPILTAGTVLPIFFIIGLIFIPIGIGIFVTSNNIRE
IEIDYTGTEPSSPCNKCLSPDVTPCFCTINFTLEKSFEGNVFMYYGLSNF
YQNHRRYVKSRDDSQLNGDSSALLNPSKECEPYRRNEDKPIAPCGAIANS
MFNDTLELFLIGNDSYPIPIALKKKGIAWWTDKNVKFRNPPGGDNLEERF
KGTTKPVNWLKPVYMLDSDPDNNGFINEDFIVWMRTAALPTFRKLYRLIE
RKSDLHPTLPAGRYSLNVTYNYPVHYFDGRKRMILSTISWMGGKNPFLGI
AYIAVGSISFLLGVVLLVINHKYR
3D structure
PDB6k7i Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
ChainC
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 C F324 I327 A328 F297 I300 A301
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0015247 aminophospholipid flippase activity
Biological Process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0010976 positive regulation of neuron projection development
GO:0015917 aminophospholipid transport
GO:0036010 protein localization to endosome
GO:0045332 phospholipid translocation
GO:0061092 positive regulation of phospholipid translocation
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0035577 azurophil granule membrane
GO:0035579 specific granule membrane
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k7i, PDBe:6k7i, PDBj:6k7i
PDBsum6k7i
PubMed31416931
UniProtQ9NV96|CC50A_HUMAN Cell cycle control protein 50A (Gene Name=TMEM30A)

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