Structure of PDB 6k1j Chain C

Receptor sequence
>6k1jC (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
KAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLTAEI
LELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQ
AVLLPKKTSATV
3D structure
PDB6k1j PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
ChainC
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C A14 R17 R20 R29 R32 R42 R77 A2 R5 R8 R17 R20 R30 R65
BS02 dna C R29 R35 R42 K75 T76 R77 R17 R23 R30 K63 T64 R65
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0042393 histone binding
GO:0046982 protein heterodimerization activity
GO:0140463 chromatin-protein adaptor activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006334 nucleosome assembly
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0010212 response to ionizing radiation
GO:0021987 cerebral cortex development
GO:0031507 heterochromatin formation
GO:0045739 positive regulation of DNA repair
GO:0051321 meiotic cell cycle
GO:0071480 cellular response to gamma radiation
GO:0090398 cellular senescence
GO:1990166 protein localization to site of double-strand break
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000794 condensed nuclear chromosome
GO:0001673 male germ cell nucleus
GO:0001741 XY body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005813 centrosome
GO:0016607 nuclear speck
GO:0035861 site of double-strand break
GO:0070062 extracellular exosome
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k1j, PDBe:6k1j, PDBj:6k1j
PDBsum6k1j
PubMed31848352
UniProtP16104|H2AX_HUMAN Histone H2AX (Gene Name=H2AX)

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