Structure of PDB 6k06 Chain C

Receptor sequence

>6k06C (length=422) Species: 10090 (Mus musculus) [Search protein sequence]

WSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFV
SFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH
AHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGY
LRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAI
SYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTD
EQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVN
HGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPL
MNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEA
LQRHENESVYKASLNLIEKYFS

3D structure

PDB

6k06 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.

Chain

Resolution

1.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	S105 W142 N146 A148 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 N239 W273 Y277 D280 G281 R315 V321 T322 K353 E354 W357 N361 K392 E396	S30 W67 N71 A73 S74 G75 T80 Q106 W109 N113 G116 D117 W156 R163 N164 W198 Y202 D205 G206 R240 V246 T247 K278 E279 W282 N286 K317 E321

External links

PDB	RCSB:6k06, PDBe:6k06, PDBj:6k06
PDBsum	6k06
PubMed	31541088
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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