Structure of PDB 6jly Chain C

Receptor sequence
>6jlyC (length=338) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
GPISEFMSTINVEHTYPAVSSLIADLKSRKVQGPFAVAVETALVMRQVIS
QTRWSTVDQLIDTVRAVGSTLVKAQPTEFSCGNIIRRILRLIREEYQELL
KTADENEKLGGMDMRAVIISGIQDVIDELDKINTDIEVQSMDHLHSNEII
LTQGCSKTVEAFLRFAAKKRKFSVIVAEGFPNNQKGSHAMAKRLAQAGID
TTVISDATIFAIMSRVNKVILGTHAILGNGGLVTYSGAQLVAQAARHHAT
PVVVCSGIYKLSPVYPYDLESIIQLSSPDKIMSFNEGDLISRAEILNPYY
DYIPPDLVDLFITNLGGYPPSYLYRIMNDTYDASDTIL
3D structure
PDB6jly Structural basis for eIF2B inhibition in integrated stress response.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 C P28 K315 P34 K260
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0044237 cellular metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jly, PDBe:6jly, PDBj:6jly
PDBsum6jly
PubMed31048492
UniProtQ9UT76|EI2BB_SCHPO Translation initiation factor eIF2B subunit beta (Gene Name=tif222)

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