Structure of PDB 6jcy Chain C

Receptor sequence
>6jcyC (length=1139) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRE
SAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDEC
KDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTE
RVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTV
GVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDE
ALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGL
HVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDH
FGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRP
VVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEV
RDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDG
VVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVP
SSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSE
APLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRM
RKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVA
IMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRD
IPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLR
AIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVY
VAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGV
PRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIV
STPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYP
VTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEME
CWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFK
VLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAAN
3D structure
PDB6jcy Structures and mechanism of transcription initiation by bacterial ECF factors.
ChainC
Resolution3.106 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C F99 R181 A210 W211 D371 T405 L463 E466 R467 V472 F77 R159 A188 W189 D349 T383 L441 E444 R445 V450
BS02 dna C G1059 A1061 R1067 M1071 G1037 A1039 R1045 M1049
BS03 rna C R465 N493 Q614 K884 K892 H1035 R443 N471 Q592 K862 K870 H1013
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jcy, PDBe:6jcy, PDBj:6jcy
PDBsum6jcy
PubMed31131408
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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