Structure of PDB 6jcl Chain C

Receptor sequence
>6jclC (length=216) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
QQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCL
LAGAIQARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVN
LQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVAYIQWAIR
LARRGAVIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQ
TVGRKGWDGFALALVR
3D structure
PDB6jcl Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis.
ChainC
Resolution1.644 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SR C D179 D181 D175 D177
BS02 SR C D139 D165 N166 D135 D161 N162
BS03 SAH C A43 V44 G68 L70 S74 E92 Y93 H97 A121 D139 A140 D141 A39 V40 G64 L66 S70 E88 Y89 H93 A117 D135 A136 D137 MOAD: Kd=12.5uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jcl, PDBe:6jcl, PDBj:6jcl
PDBsum6jcl
PubMed31147608
UniProtO07431|CAMT_MYCTU Catechol O-methyltransferase (Gene Name=Rv0187)

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