Structure of PDB 6jat Chain C

Receptor sequence

>6jatC (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]

SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVT
FDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNS
FWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYF
YKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLAL
IPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAE
FVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFAL
HFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSW
DNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLG
EKEILEKAVKSAAVNREYYRQQ

3D structure

PDB

6jat Crystal structure of SETD3 bound to Actin peptide and SFG

Chain

Resolution

2.713 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.85: protein-histidine N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	N153 I154 R214 Q215 Q254 N255 W273 D274 I283 T285 G286 Y287 Y312 R315 H323	N134 I135 R195 Q196 Q235 N236 W254 D255 I264 T266 G267 Y268 Y293 R296 H304
BS02	SFG	C	R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326 F328	R55 E84 F86 R234 D255 M256 N258 H259 Y293 S305 F307 F309

Gene Ontology

	Molecular Function
GO:0018064	protein-L-histidine N-tele-methyltransferase activity

	Biological Process
GO:0030047	actin modification

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Molecular Function

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Biological Process

External links

PDB	RCSB:6jat, PDBe:6jat, PDBj:6jat
PDBsum	6jat
PubMed
UniProt	Q86TU7\|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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