Structure of PDB 6j8y Chain C

Receptor sequence
>6j8yC (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
YSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAF
IQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPTLTALRMCYQGYGY
PLMLFLEEGGVVTVCKINTQEPTLDFDFCSTNVINKIILQSEGLREAFSE
LDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQ
VNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEY
YCCPD
3D structure
PDB6j8y Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C N47 G48 I49 F64 Q66 K155 I157 K240 R244 Q254 M256 F266 N33 G34 I35 F50 Q52 K136 I138 K221 R225 Q235 M237 F247
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0021762 substantia nigra development
GO:0051598 meiotic recombination checkpoint signaling
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0030896 checkpoint clamp complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j8y, PDBe:6j8y, PDBj:6j8y
PDBsum6j8y
PubMed31776186
UniProtO60671|RAD1_HUMAN Cell cycle checkpoint protein RAD1 (Gene Name=RAD1)

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