Structure of PDB 6iwa Chain C

Receptor sequence

>6iwaC (length=427) Species: 10090 (Mus musculus) [Search protein sequence]

QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

6iwa Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	S105 R106 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 N239 W273 Y277 D280 G281 R315 N319 T322 G323 K353 W357 N361 E396 W399 D433	S35 R36 F68 W72 N76 S79 G80 T85 Q111 W114 N118 G121 D122 W161 R168 N169 W203 Y207 D210 G211 R245 N249 T252 G253 K283 W287 N291 E326 W329 D363

External links

PDB	RCSB:6iwa, PDBe:6iwa, PDBj:6iwa
PDBsum	6iwa
PubMed	31541088
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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