Structure of PDB 6iw8 Chain C

Receptor sequence

>6iw8C (length=419) Species: 10090 (Mus musculus) [Search protein sequence]

WSVEDIVKGINSNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVS
FLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHA
HISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYL
RNLTWTLSNLCRNNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISY
LTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQ
TQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHG
LVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMN
LLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQ
RHNESVYKASLNLIEKYFS

3D structure

PDB

6iw8 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 W273 D280 G281 R315 V321 T322 G323 E354 W357 N361 K392 E396	W66 N70 S73 G74 T79 Q105 W108 N112 D116 W155 R162 W196 D203 G204 R238 V244 T245 G246 E277 W280 N284 K315 E319

External links

PDB	RCSB:6iw8, PDBe:6iw8, PDBj:6iw8
PDBsum	6iw8
PubMed	31541088
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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