Structure of PDB 6isp Chain C

Receptor sequence
>6ispC (length=319) Species: 84753 (Moesziomyces antarcticus) [Search protein sequence]
MALPSGSDPAFSQPKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSF
DSNWIPLSAQLGYTPCWISPPPFMLNDTQVNTEYMVNAITTLYAGSGNNK
LPVLTVSQGGLVAQWGLTFFPSIRSKVDRLMAFAPDYKGTVLAGPLDALA
GSAPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSP
LDSSYLFNGKNVQAQAVCGPLFVIDHAGSLTSQFSYVVGRSALRSTTGQA
RSADYGITDCNPLPANDLTPEQKVAAAALLAPYYAAIVAGPKQNCEPDLM
PYARPFAVGKRTCSGIVTP
3D structure
PDB6isp Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution.
ChainC
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CPQ C T186 V194 P218 T188 V196 P220
BS02 CPQ C F71 A283 A287 F73 A285 A289
BS03 CPQ C P143 Y282 P145 Y284
Gene Ontology
Molecular Function
GO:0004806 triacylglycerol lipase activity
GO:0016787 hydrolase activity
Biological Process
GO:0016042 lipid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6isp, PDBe:6isp, PDBj:6isp
PDBsum6isp
PubMed31324776
UniProtP41365|LIPB_PSEA2 Lipase B

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