Structure of PDB 6ijr Chain C

Receptor sequence
>6ijrC (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK
SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ
EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG
QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS
GDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQ
IVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
3D structure
PDB6ijr Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.
ChainC
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K301 Q314 V315 L318 K319 E471 K107 Q120 V121 L124 K125 E277
BS02 A9C C H266 F282 C285 R288 S289 Y327 L330 I341 S342 F363 M364 H72 F88 C91 R94 S95 Y133 L136 I147 S148 F169 M170
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ijr, PDBe:6ijr, PDBj:6ijr
PDBsum6ijr
PubMed31371757
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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