Structure of PDB 6ict Chain C

Receptor sequence

>6ictC (length=479) Species: 9606 (Homo sapiens)

VSPKEILNLTSELLQKCSSPAPGKEWEEYVQIRTLVEKIRKKQKGLSVTF
DGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFL
WVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSF
WQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFY
KVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALI
PLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEF
VIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALH
FTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWD
NEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGE
KEILEKAVKSAAVNREYYRQQMEEKAPLP

3D structure

• PDB: 6ict Structural insights into SETD3-mediated histidine methylation on beta-actin.
• Chain: C
• Resolution: 1.952 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.85: protein-histidine N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	R147 A151 M152 N154 I155 N212 R215 Q216 R254 Q255 N256 W274 D275 T286 G287 Y288 Y313 R316	R126 A130 M131 N133 I134 N191 R194 Q195 R233 Q234 N235 W253 D254 T265 G266 Y267 Y292 R295
BS02	SAH	C	R75 E104 F106 R254 D275 M276 N278 H279 Y313 S325 F327	R54 E83 F85 R233 D254 M255 N257 H258 Y292 S304 F306

Gene Ontology

Molecular Function

• GO:0018064 protein-L-histidine N-tele-methyltransferase activity

Biological Process

• GO:0030047 actin modification

External links

• PDB: RCSB:6ict, PDBe:6ict, PDBj:6ict
• PDBsum: 6ict
• PubMed: 30785395
• UniProt: Q86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)