Structure of PDB 6hzv Chain C

Receptor sequence
>6hzvC (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQGPDQQR
DFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARL
DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLA
KLLPLDKDYYVVSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDK
SCSPSAEFLRMPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQ
DRPSFSALGPQLDML
3D structure
PDB6hzv Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
ChainC
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 R953 N954 D967
Catalytic site (residue number reindexed from 1) D128 R132 N133 D146
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GYW C L828 K830 G831 A853 M902 Y904 L905 G908 C909 D912 L956 L14 K16 G17 A39 M81 Y83 L84 G87 C88 D91 L135 MOAD: ic50=59nM
BindingDB: IC50=59nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hzv, PDBe:6hzv, PDBj:6hzv
PDBsum6hzv
PubMed31609613
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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