Structure of PDB 6hyu Chain C

Receptor sequence
>6hyuC (length=585) Species: 9606 (Homo sapiens) [Search protein sequence]
YKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQ
PRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLL
RECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTS
ATLDAVKFSQYFYEAPIFTIPGTYPVEILYTKDASLITVMQIHLTEPPGD
ILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIF
DPAPPGSRKVVIATNIAETLTIDGIYYVVDPGFVKQKVVQAQAKQRAGRA
GRTGPGKCYRLYTERAYRDEMLTPEIQRTNLASTVLSLKAMGINDLLPME
TLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCS
EEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW
KNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVR
VQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYH
ELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPT
3D structure
PDB6hyu Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
ChainC
Resolution3.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C Q783 K861 K863 Q208 K285 K287
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome

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Molecular Function
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Biological Process
External links
PDB RCSB:6hyu, PDBe:6hyu, PDBj:6hyu
PDBsum6hyu
PubMed31409651
UniProtQ14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 (Gene Name=DHX8)

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