Structure of PDB 6hyt Chain C

Receptor sequence
>6hytC (length=632) Species: 9606 (Homo sapiens) [Search protein sequence]
SILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAG
YTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPET
VIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQ
KRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDY
LDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPE
LIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVD
PGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTER
AYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLIT
AMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEML
TIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNK
FSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKA
ICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVL
TTKEYMREVTTIDPRWLVEFAPAFFKVSDPTK
3D structure
PDB6hyt Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
ChainC
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C T590 G591 S592 G593 K594 T595 T596 S625 R629 F825 T847 D849 T34 G35 S36 G37 K38 T39 T40 S69 R73 F269 T291 D293
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome

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Molecular Function
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Biological Process
External links
PDB RCSB:6hyt, PDBe:6hyt, PDBj:6hyt
PDBsum6hyt
PubMed31409651
UniProtQ14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 (Gene Name=DHX8)

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