Structure of PDB 6hrq Chain C

Receptor sequence
>6hrqC (length=419) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDS
PSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDC
PGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGF
CYLNDIVLAIHRLVSSTQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVH
HASPGFFPGTGTWNDNDKLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNA
IGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAI
KKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIP
EHSYFSRYGPDFELDIDYFPHETLDSIQKHHRRILEQLRNYADLNKLIYD
YDQVYQLYNLTGMGSLVPR
3D structure
PDB6hrq Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
ChainC
Resolution1.845 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D186 H188 D285 D177 H179 D274
BS02 GM5 C K20 H141 H142 F151 D186 H188 F216 P291 H292 Y341 K19 H140 H141 F150 D177 H179 F207 P280 H281 Y318 MOAD: Kd=81.7nM
BindingDB: IC50=95nM,Kd=82nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hrq, PDBe:6hrq, PDBj:6hrq
PDBsum6hrq
PubMed30347148
UniProtA5H660

[Back to BioLiP]