Structure of PDB 6hky Chain C

Receptor sequence
>6hkyC (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTME
GERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNE
ELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK
GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL
AGSENNQSLLTLGRVITALVPYRESKLTRILQDSLGGRTRTSIIATISPA
SLNLEETLSTLEYAHRAKNILNKP
3D structure
PDB6hky Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C P27 T107 G108 G110 K111 T112 F113 P11 T91 G92 G94 K95 T96 F97
BS02 GCE C E116 G117 A133 I136 P137 Y211 G217 A218 R221 E100 G101 A117 I120 P121 Y195 G201 A202 R205 BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:6hky, PDBe:6hky, PDBj:6hky
PDBsum6hky
PubMed31488701
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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