Structure of PDB 6hio Chain C

Receptor sequence
>6hioC (length=385) Species: 10090 (Mus musculus) [Search protein sequence]
QPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVL
TTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGK
SPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYA
EMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITL
LLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLV
HKQDLQRPVPDWLRHLVLDRIAWIRGLLQELSSIRHFLEKRDEMREVARD
WLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIAW
3D structure
PDB6hio Conformational transitions of the serotonin 5-HT3receptor.
ChainC
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRO C W156 Y207 W148 Y199 BindingDB: Ki=361nM,EC50=3400nM
BS02 SRO C W63 Y64 R65 Y126 W55 Y56 R57 Y118 BindingDB: Ki=361nM,EC50=3400nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:6hio, PDBe:6hio, PDBj:6hio
PDBsum6hio
PubMed30401839
UniProtP23979|5HT3A_MOUSE 5-hydroxytryptamine receptor 3A (Gene Name=Htr3a)

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