Structure of PDB 6hd1 Chain C

Receptor sequence
>6hd1C (length=436) Species: 9606 (Homo sapiens) [Search protein sequence]
QETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYS
EAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNA
EYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMD
IVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYC
VIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAIL
QLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVR
WRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLP
SVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPA
AYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWE
3D structure
PDB6hd1 Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
ChainC
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.1.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0008823 cupric reductase (NADH) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
GO:0071949 FAD binding
Biological Process
GO:0006826 iron ion transport
GO:0015677 copper ion import
GO:0033212 iron import into cell
GO:0045444 fat cell differentiation
GO:0070207 protein homotrimerization
GO:0098706 iron ion import across cell outer membrane
Cellular Component
GO:0000139 Golgi membrane
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0031901 early endosome membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hd1, PDBe:6hd1, PDBj:6hd1
PDBsum6hd1
PubMed30337524
UniProtQ687X5|STEA4_HUMAN Metalloreductase STEAP4 (Gene Name=STEAP4)

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