Structure of PDB 6h7f Chain C

Receptor sequence

>6h7fC (length=671) Species: 470 (Acinetobacter baumannii)

DTYAGGQVATSSNVGFLGSKKFLDTPFNTISYTDKYIEDKQAKDITEVIA
ATDPSIYTNGASGGWSENYYIRGYASSTNDMSMNGLFGITPFYRTSPEMF
GRVEVLKGPSALLNGMPPAGSVGGTVNLVTKYAADEPFARLTTTYMSDAQ
FGGHVDVGRRFGENKEFGVRINGMYRDGDAAVNDQSKESRLFSLGLDWQG
ENARVFVDAYDALDHVDGVTRGVNVSTAVGIPKPPKADTLLSPDWGSVET
KDKGAMIRGEYDFSDQLMAYAAYGQSTTEYKYNGASAGTITSSTGTLSST
LGQLAFDVDKKSADAGFKGKFETGSVKHQWVANATYYNHTQDDYGYRIIP
GFSDPVITNIYDPNPNWGPKPEFTPPFLFHSTLSTSSFGLADTLSFAQDK
VQLTLGLRHQTVKATSSVNTLPENAKSATTPGVALLIKATDKISVYANYI
EGLTKGDQAPATASNPGEIFPPQKTKQQELGLKVDLGTFAHTLSAFEITK
PSSYLDPSKLVNNLPTFVSDGEQRNRGIEWSFFGSPIEHVRLMGGFTYLD
PELTKTKSGGNDGHTAVAVPKNQAKLGAEWDTQVAQGTLTLSGNINAVSK
QYINAENTLSVPGRTLLDVGARYSTKVEDHPVTFRANIYNLTNKAYWAQP
QLTNLALGAPRTYMLSVSYDF

3D structure

• PDB: 6h7f Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogenAcinetobacter baumannii.
• Chain: C
• Resolution: 2.26 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FV8	C	W97 Y125 R253 Y312 Y314 L336 Y378	W65 Y93 R221 Y280 Y282 L304 Y346
BS02	OPZ	C	R253 L684	R221 L652
BS03	C8E	C	N480 Q510	N448 Q478
BS04	C8E	C	R222 D243	R190 D211
BS05	C8E	C	Y302 A347	Y270 A315
BS06	C8E	C	F578 Y580	F546 Y548
BS07	C8E	C	D339 P407	D307 P375

Gene Ontology

Molecular Function

• GO:0015343 siderophore-iron transmembrane transporter activity
• GO:0015344 siderophore uptake transmembrane transporter activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006826 iron ion transport
• GO:0015891 siderophore transport
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane

External links

• PDB: RCSB:6h7f, PDBe:6h7f, PDBj:6h7f
• PDBsum: 6h7f
• PubMed: 30558715
• UniProt: Q76HJ9