Structure of PDB 6gyr Chain C

Receptor sequence
>6gyrC (length=575) Species: 9606 (Homo sapiens) [Search protein sequence]
KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS
PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKL
SEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQ
NRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFV
ECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPS
TRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVD
SGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYI
SYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDD
YIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDRL
TSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTNDLSQKLYATME
KHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHL
EFSSLRRAQWSTMCMLVELHTQSQD
3D structure
PDB6gyr Transcription factor dimerization activates the p300 acetyltransferase.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1164 H1255 C119 H210
BS02 ZN C C1247 C1250 C1275 C202 C205 C230
BS03 01K C Y1397 L1398 D1399 S1400 R1410 T1411 Y1414 W1436 P1440 Y1446 K1456 P1458 R1462 L1463 W1466 F1467 Y352 L353 D354 S355 R365 T366 Y369 W391 P395 Y401 K411 P413 R417 L418 W421 F422
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6gyr, PDBe:6gyr, PDBj:6gyr
PDBsum6gyr
PubMed30323286
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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