Structure of PDB 6gym Chain C

Receptor sequence

>6gymC (length=262) Species: 559292 (Saccharomyces cerevisiae S288C)

EGPQVKIREASKDNVDFILSNVDLAMANSLRRVMIAEIPTLAIDSVEVET
NTTVLADEFIAHRLGLIPLQSMDIEQLEYSRDCFCEDHCDKCSVVLTLQA
FGESESTTNVYSKDLVIVSNLMGRNIGHPIIQDKEGNGVLICKLRKGQEL
KLTCVAKKGIAKEHAKWGPAAAIEFEYDPWNKLKHTDYWYEQDSAKEWPQ
SKNCEYEDPPNEGDPFDYKAQADTFYMNVESVGSIPVDQVVVRGIDTLQK
KVASILLALTQM

3D structure

• PDB: 6gym Promoter Distortion and Opening in the RNA Polymerase II Cleft.
• Chain: C
• Resolution: 6.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	C	H91 C92	H88 C89

Gene Ontology

Molecular Function

• GO:0001055 RNA polymerase II activity
• GO:0003677 DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding
• GO:0046983 protein dimerization activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0006366 transcription by RNA polymerase II
• GO:0006367 transcription initiation at RNA polymerase II promoter
• GO:0006368 transcription elongation by RNA polymerase II
• GO:0006369 termination of RNA polymerase II transcription

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005665 RNA polymerase II, core complex
• GO:0055029 nuclear DNA-directed RNA polymerase complex

External links

• PDB: RCSB:6gym, PDBe:6gym, PDBj:6gym
• PDBsum: 6gym
• PubMed: 30472190
• UniProt: P16370|RPB3_YEAST DNA-directed RNA polymerase II subunit RPB3 (Gene Name=RPB3)