Structure of PDB 6gxg Chain C

Receptor sequence
>6gxgC (length=147) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
GAMGSGLAKYLPGATNLLSKSGEVSLGSLVGKTVFLYFSASWCPPCRGFT
PVLAEFYEKHHVAKNFEVVLISWDENESDFHDYYGKMPWLALPFDQRSTV
SELGKTFGVESIPTLITINADTGAIIGTQARTRVIEDPDGANFPWPN
3D structure
PDB6gxg Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
ChainC
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FFN C W39 C40 P41 I109 W42 C43 P44 I112
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gxg, PDBe:6gxg, PDBj:6gxg
PDBsum6gxg
PubMed30605929
UniProtO77404|TYPX_TRYBB Tryparedoxin

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