Structure of PDB 6gr2 Chain C

Receptor sequence
>6gr2C (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
LRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVL
PMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGT
PRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFL
QQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDC
RSLETSLVPLSDPKLAVLITNSNVRHSSEYPVRRRQCEEVARALGAASLR
EVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRL
MVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLL
EASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6gr2 Structure of human galactokinase in complex with galactose and ADP
ChainC
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL C E43 H44 D46 C182 G183 D186 Y236 G346 E40 H41 D43 C179 G180 D183 Y230 G340
BS02 ADP C T77 S79 W106 Y109 L135 G136 G138 S140 S141 S142 L145 T74 S76 W103 Y106 L132 G133 G135 S137 S138 S139 L142
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gr2, PDBe:6gr2, PDBj:6gr2
PDBsum6gr2
PubMed
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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