Structure of PDB 6fmk Chain C

Receptor sequence
>6fmkC (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHS
YRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKER
CLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLT
3D structure
PDB6fmk Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DV8 C W88 Y98 P99 I109 H110 S111 Y112 H115 W117 W27 Y37 P38 I48 H49 S50 Y51 H54 W56 PDBbind-CN: -logKd/Ki=4.67,Kd=21.6uM
External links
PDB RCSB:6fmk, PDBe:6fmk, PDBj:6fmk
PDBsum6fmk
PubMed29650462
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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