Structure of PDB 6fkj Chain C

Receptor sequence
>6fkjC (length=439) Species: 9913 (Bos taurus) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNT
FFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAAN
NYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTS
LLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCA
FMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVD
LTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQ
MVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGF
KVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAK
RAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV
3D structure
PDB6fkj High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.
ChainC
Resolution2.148 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP C Q11 A12 Q15 A99 N101 S140 G143 G144 T145 G146 E183 N206 Y224 N228 Q10 A11 Q14 A98 N100 S139 G142 G143 T144 G145 E182 N205 Y223 N227
BS02 CA C D39 T41 G44 E55 D38 T40 G43 E54
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fkj, PDBe:6fkj, PDBj:6fkj
PDBsum6fkj
PubMed29523799
UniProtP81947|TBA1B_BOVIN Tubulin alpha-1B chain

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