Structure of PDB 6exw Chain C

Receptor sequence
>6exwC (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
FSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFC
CDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHL
3D structure
PDB6exw Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C3K C D297 G306 L307 R308 C309 W310 D314 E319 W323 D45 G54 L55 R56 C57 W58 D62 E67 W71
BS02 ZN C C300 C303 H320 C327 C48 C51 H68 C75
BS03 C3K C R308 C309 R56 C57
External links
PDB RCSB:6exw, PDBe:6exw, PDBj:6exw
PDBsum6exw
PubMed30055105
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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