Structure of PDB 6esq Chain C

Receptor sequence
>6esqC (length=392) Species: 2186 (Methanothermococcus thermolithotrophicus) [Search protein sequence]
MRDVAIIGYGQTKFGELWEDSFRDLIVEAGVKAIKDANVDGGDIDAMYIG
NMSGGLFVGQEHIASLIADHAGLNPVPCTRVEAACASGSLALRSAVLSVA
SGHHDVVLAGGVEKMTDVEDATAAIASASDQEWEAFFGATFPSLYAMMAR
RYMYQYGLTIEELSMWSVIAHENATKNKYAQFGFKTTLEQVMNASPVADP
LTLMHCSPVSDGASALIVCDADKAEEFAPKDEIIYIKASTQASDTIALHD
REDMTTLNAAKVASEKAYKLAKIAPEKIDVAEVHDCFAINGLILVEDLGF
CKKGDAGKVIDEGKIRIDYDDFVTVNPSGGLKAAGHALGATGIRQVGELY
WQLKQDKECKDRQATIKNGYGIAANVGGTGGTVCVHLLSDKR
3D structure
PDB6esq Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
ChainC
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA C F182 L203 M204 C206 S207 P208 V209 K332 F182 L203 M204 C206 S207 P208 V209 K332
Gene Ontology
Molecular Function
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:6esq, PDBe:6esq, PDBj:6esq
PDBsum6esq
PubMed29531083
UniProtA0A384E138

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