Structure of PDB 6en4 Chain C

Receptor sequence
>6en4C (length=842) Species: 9606 (Homo sapiens) [Search protein sequence]
NLPFLKPDDIQYFDKLLVDVDESTLSPEEQKERKIMKLLLKIKNGTPPMR
KAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYK
LDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMIST
MRPDIDNMDEYVRNTTARAFAVVASALGIPSLLPFLKAVCKSKKSWQARH
TGIKIVQQIAILMGCAILPHLRSLVEIIEHGLVDEQQKVRTISALAIAAL
AEAATPYGIESFDSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYA
NYYTREVMLILIREFQSPDEEMKKIVLKVVKQCCGTDGVEANYIKTEILP
PFFKHFWQHRMALDRRNYRQLVDTTVELANKVGAAEIISRIVDDLKDEAE
QYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGILYAFQEQTTEDSVMLN
GFGTVVNALGKRVKPYLPQICGTVLWRLNNKSAKVRQQAADLISRTAVVM
KTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKMTPP
IKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFEL
LELLKAHKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQNRVCT
TVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMG
KDYIYAVTPLLEDALMDRDLVHRQTASAVVQHMSLGVYGFGCEDSLNHLL
NYVWPNVFETSPHVIQAVMGALEGLRVAIGPCRMLQYCLQGLFHPARKVR
DVYWKIYNSIYIGSQDALIAHYPRIYNDDKNTYIRYELDYIL
3D structure
PDB6en4 Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
ChainC
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGZ C K1071 R1074 R1075 V1078 V1110 F1153 Y1157 K609 R612 R613 V616 V648 F691 Y695 PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
Gene Ontology
Biological Process
GO:0000245 spliceosomal complex assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:6en4, PDBe:6en4, PDBj:6en4
PDBsum6en4
PubMed29656923
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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