Structure of PDB 6ebv Chain C

Receptor sequence
>6ebvC (length=267) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLT
GGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTG
TSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRN
TIDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVV
GEVVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYY
VENGAFSGAIGALYLEK
3D structure
PDB6ebv Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 27Q C V156 L171 T172 E202 Y240 V156 L171 T172 E202 Y240
BS02 ADP C G8 G9 T10 L11 K13 L28 G98 T99 G121 G122 Q125 Y137 S225 G8 G9 T10 L11 K13 L28 G98 T99 G121 G122 Q125 Y137 S225
BS03 27Q C E70 F71 R113 G116 I117 E70 F71 R113 G116 I117
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ebv, PDBe:6ebv, PDBj:6ebv
PDBsum6ebv
PubMed
UniProtQ2FWC7|COAW_STAA8 Type II pantothenate kinase (Gene Name=coaW)

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