Structure of PDB 6e6p Chain C

Receptor sequence
>6e6pC (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGDVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB6e6p Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
ChainC
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C D13 G15 K16 S17 A18 F28 V29 D30 P34 T35 G60 N116 K117 D119 L120 S145 D13 G15 K16 S17 A18 F28 V29 D30 P34 T35 G60 N116 K117 D119 L120 S145
BS02 MG C S17 T35 S17 T35
BS03 CA C E3 E76 E3 E76
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6e6p, PDBe:6e6p, PDBj:6e6p
PDBsum6e6p
PubMed31390567
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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