Structure of PDB 6e1h Chain C

Receptor sequence
>6e1hC (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
CGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERF
KELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLR
VTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWV
YYESKAHIHCSVKA
3D structure
PDB6e1h Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C E89 D95 T125 E126 E66 D72 T102 E103
BS02 CA C E89 E90 D95 E126 D129 E66 E67 D72 E103 D106
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:6e1h, PDBe:6e1h, PDBj:6e1h
PDBsum6e1h
PubMed30139912
UniProtQ15465|SHH_HUMAN Sonic hedgehog protein (Gene Name=SHH)

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