Structure of PDB 6dz2 Chain C

Receptor sequence
>6dz2C (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
AVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLL
TIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFID
RTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHS
KGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASI
AMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSE
TLHNLKNMAQFSVLLP
3D structure
PDB6dz2 Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
ChainC
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T18 P41 I67 M68 A94 M196 T197 D220 D222 V233
Catalytic site (residue number reindexed from 1) T10 P33 I52 M53 A79 M181 T182 D205 D207 V218
Enzyme Commision number 2.4.2.28: S-methyl-5'-thioadenosine phosphorylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 OS5 C T18 A94 C95 G96 F177 I194 N195 M196 D220 D222 V236 L240 T10 A79 C80 G81 F162 I179 N180 M181 D205 D207 V221 L225 MOAD: Kd=1.4nM
PDBbind-CN: -logKd/Ki=8.85,Kd=1.4nM
BindingDB: Kd=1.4nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0017061 S-methyl-5-thioadenosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006166 purine ribonucleoside salvage
GO:0006738 nicotinamide riboside catabolic process
GO:0009116 nucleoside metabolic process
GO:0019509 L-methionine salvage from methylthioadenosine
GO:0032259 methylation
GO:0033574 response to testosterone
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6dz2, PDBe:6dz2, PDBj:6dz2
PDBsum6dz2
PubMed30860833
UniProtQ13126|MTAP_HUMAN S-methyl-5'-thioadenosine phosphorylase (Gene Name=MTAP)

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