Structure of PDB 6dk1 Chain C

Receptor sequence
>6dk1C (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
QWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAG
LDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLS
EYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGET
VVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFY
TLRSYARGLRLELTTYLFGQ
3D structure
PDB6dk1 Structural basis for sigma1receptor ligand recognition.
ChainC
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GM4 C V84 Y103 L105 F107 W164 E172 A185 V83 Y102 L104 F106 W163 E171 A184 BindingDB: Ki=3.1nM,Kd=11.6nM,IC50=8.2nM
Gene Ontology
Molecular Function
GO:0004985 G protein-coupled opioid receptor activity
GO:0005515 protein binding
GO:0038023 signaling receptor activity
Biological Process
GO:0006869 lipid transport
GO:0007399 nervous system development
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0043523 regulation of neuron apoptotic process
GO:0070207 protein homotrimerization
GO:0150052 regulation of postsynapse assembly
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030426 growth cone
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0070161 anchoring junction
GO:0098794 postsynapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dk1, PDBe:6dk1, PDBj:6dk1
PDBsum6dk1
PubMed30291362
UniProtQ99720|SGMR1_HUMAN Sigma non-opioid intracellular receptor 1 (Gene Name=SIGMAR1)

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