Structure of PDB 6dhd Chain C

Receptor sequence

>6dhdC (length=501) Species: 9913 (Bos taurus)

ADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRGILR
IIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVS
VDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTM
ELAKKGFIGPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTG
KPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFAVQ
GFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGT
ILGFPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANG
PTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFK
YERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVH
SGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFRVYNEAGVTF
T

3D structure

• PDB: 6dhd Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation.
• Chain: C
• Resolution: 2.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K126 D168
• Catalytic site (residue number reindexed from 1): K126 D168
• Enzyme Commision number: 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAI	C	H85 R86 T87 A116 D119 R491	H85 R86 T87 A116 D119 R491
BS02	GLU	C	K90 M111 K114 K126 A166 R211 G377 V378 S381	K90 M111 K114 K126 A166 R211 G377 V378 S381
BS03	GTP	C	H209 S213 R217 H258 R261 Y262 R265 E292 H450	H209 S213 R217 H258 R261 Y262 R265 E292 H450
BS04	NAI	C	R94 D168 M169 T215 Q250 G253 N254 V255 E275 S276 A326 A348 N349 N374	R94 D168 M169 T215 Q250 G253 N254 V255 E275 S276 A326 A348 N349 N374
BS05	NAI	C	H195 Q205 G206 K387 N388 H391 S393	H195 Q205 G206 K387 N388 H391 S393

Gene Ontology

Molecular Function

• GO:0004352 glutamate dehydrogenase (NAD+) activity
• GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
• GO:0004354 glutamate dehydrogenase (NADP+) activity
• GO:0005524 ATP binding
• GO:0005525 GTP binding
• GO:0016491 oxidoreductase activity
• GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0006538 glutamate catabolic process
• GO:0006541 glutamine metabolic process
• GO:0072350 tricarboxylic acid metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:6dhd, PDBe:6dhd, PDBj:6dhd
• PDBsum: 6dhd
• PubMed: 11254391
• UniProt: P00366|DHE3_BOVIN Glutamate dehydrogenase 1, mitochondrial (Gene Name=GLUD1)