Structure of PDB 6dcf Chain C

Receptor sequence
>6dcfC (length=858) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
VPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGEEN
PVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTYAA
PLFVTAIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRFGNRRLRTV
GELIQNQIRVGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFF
GTSQLSQFMDQNNPLSGLTHKRRLLALGVHPSHYGRMCPIETPEGPNIGL
IGSLSVYARVNPFGFIETPYRKVVTDQIDYLTADEEDRHVMDVSPRQMVS
VATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDA
GDVVVADKTGVIEEVSADYITVMADDGTRQSYRLRKFARSNHGTCANQRP
IVDAGQRVEAGQVIADGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILS
NRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERG
IVRIGAEVRDGDILVGKVTPKGETTPEERLLRAIFGEKAREVRDTSLKVP
HGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHG
NKGVIGKILPVEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVA
KAGWNIDVAAGVPDWASKLPEELYSAPADSTVATPVFDGAQEGELAGLLG
STLPNRDGEVMVDADGKSTLFDGRSGEPFPYPVTVGYMYILKLHHLVDDK
IHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLT
IKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSS
DGAAIEMR
3D structure
PDB6dcf Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
ChainC
Resolution3.45 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KNG C G423 S425 Q426 S428 Q429 F430 D432 R445 I488 R604 G201 S203 Q204 S206 Q207 F208 D210 R223 I251 R325
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6dcf, PDBe:6dcf, PDBj:6dcf
PDBsum6dcf
PubMed30297823
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

[Back to BioLiP]