Structure of PDB 6dc6 Chain C

Receptor sequence
>6dc6C (length=996) Species: 9606 (Homo sapiens) [Search protein sequence]
DIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKA
VTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYT
GPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQL
FCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFV
SFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVP
KKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPR
PRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPIN
AFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKCLQRQ
NRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGG
EIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSH
QNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLES
GTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPIATLKNFPNAIEHTLQWA
RDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQ
RPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRC
PHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPE
FTPKSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDF
IVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYK
VVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQ
GLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERL
DQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTI
3D structure
PDB6dc6 Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
ChainC
Resolution3.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R57 R515 D576 A632 T633 K635
Catalytic site (residue number reindexed from 1) R9 R467 D528 A584 T585 K587
Enzyme Commision number 6.2.1.45: E1 ubiquitin-activating enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D506 E509 D458 E461
BS02 POP C R57 N512 K528 R9 N464 K480
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004839 ubiquitin activating enzyme activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016874 ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 DNA damage response
GO:0016567 protein ubiquitination
GO:0032446 protein modification by small protein conjugation
GO:0036211 protein modification process
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0030057 desmosome
GO:0030867 rough endoplasmic reticulum membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dc6, PDBe:6dc6, PDBj:6dc6
PDBsum6dc6
PubMed30279270
UniProtP22314|UBA1_HUMAN Ubiquitin-like modifier-activating enzyme 1 (Gene Name=UBA1)

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