Structure of PDB 6cz7 Chain C

Receptor sequence

>6cz7C (length=807) Species: 94122 (Shewanella sp. ANA-3)

LRRTGVGEWLATTCQGCTSWCAKQIYVMDGRALKVRGNPNSGVHGMSSCP
RQHLSLQQVYDPDRLRTPMMRTNPKKGRDQDPKFVPISWDKALDMLADKI
IALRVANEPHKYALLRGRYSHINDLLYKKMTNLIGSPNNISHSSVCAEAH
KMGPYYLDGNWGYNQYDVKNAKFILSFGADPIASNRQVSFYSQTWGDSLD
HAKVVVVDPRLSASAAKAHKWIPIEPGQDSVLALAIAHVALVEGVWHKPF
VGDFIEGKNLFKAGKTVSVESFKETHTYGLVEWWNQALKDYTPEWASKIT
GIDPKTIIAIAKDMGAAAPAVQVWTSRGAVMQARGTYTSISCHALNGLFG
GIDSKGGLFPGNKTPLLKEYPEAKAYMDEIAAKGVKKEKIDQRGRLEFPA
LAKGKSGGGVITANAANGIRNQDPYEIKVMLAYFNNFNFSNPEGQRWDEA
LSKVDFMAHITTNVSEFSWFADVLLPSSHHMFEKWGVLDSIGNGVAQISI
QQPSIKRLWDTRIDESEIPYMLAKKLADKGFDAPWRYINEQIVDPETGKP
AADEAEFAKLMVRYLTAPLWKEDASKYGDKLSSWDEFVQKGVWNSSPYKL
EARWGKFKTETTKFEFYSKTLEKALQSHADKHKVSIDEVMKACDYQARGH
LAFIPHYEEPYRFGDESEFPLLLVDQKSRLNKEGRTANSPWYYEFKDVDP
GDVANEDVAKFNPIDGKKFGLKDGDEIRITSPVGMLTCKAKLWEGVRPGT
VAKCFGQGHWAYGRYASAKFGVTPRGGSNNDLIADRYDRLSGASAFYGHI
RVRVEKV

3D structure

• PDB: 6cz7 Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations.
• Chain: C
• Resolution: 1.62 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R98 C193 A194 R374
• Catalytic site (residue number reindexed from 1): R51 C146 A147 R327
• Enzyme Commision number: 1.20.99.1: arsenate reductase (donor).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	C	C61 G63 C64 S66 W67 C68 K70 C96 R98 V235 S236	C14 G16 C17 S19 W20 C21 K23 C49 R51 V188 S189
BS02	MGD	C	C64 T65 R98 G225 A230 S231 N232 D255 P256 R257 P273 D276 S373 R374 G375 V721 D722 K724 S725 R726 N728 E730 Y844	C17 T18 R51 G178 A183 S184 N185 D208 P209 R210 P226 D229 S326 R327 G328 V674 D675 K677 S678 R679 N681 E683 Y797
BS03	MGD	C	H189 V192 C193 R374 F481 N482 N483 F484 S487 T508 T509 S512 S524 H527 D561 D722 K724 E730 G731 R732 F802 Y809 N827 F843	H142 V145 C146 R327 F434 N435 N436 F437 S440 T461 T462 S465 S477 H480 D514 D675 K677 E683 G684 R685 F755 Y762 N780 F796

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:6cz7, PDBe:6cz7, PDBj:6cz7
• PDBsum: 6cz7
• PubMed: 30104376
• UniProt: Q7WTU0|ARRA_SHESA Arsenate respiratory reductase molybdopterin-containing subunit ArrA (Gene Name=arrA)