Structure of PDB 6cym Chain C

Receptor sequence
>6cymC (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
3D structure
PDB6cym Reversible covalent direct thrombin inhibitors.
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D113 E216 G217 D218 S219 G220
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C E22 G24 M25 P27 W28 D127 H130 P131 V132 C133 Y148 K149 R151 N178 K226 P228 N231 R232 W233 E8 G10 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 R137 N164 K212 P214 N217 R218 W219
BS02 71F C A214 S219 V239 S240 W241 A200 S205 V225 S226 W227
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6cym, PDBe:6cym, PDBj:6cym
PDBsum6cym
PubMed30071045
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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