Structure of PDB 6cu6 Chain C

Receptor sequence
>6cu6C (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGARGVGKSALTIQLIQNHFVDSYRKQVVIDGETCLLDILD
TAQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNK
CDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK
E
3D structure
PDB6cu6 Atypical KRASG12RMutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
ChainC
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S17 D57 S18 D50
BS02 GNP C G13 G15 K16 S17 A18 F28 V29 N116 K117 D119 L120 S145 A146 G14 G16 K17 S18 A19 F29 V30 N99 K100 D102 L103 S128 A129
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cu6, PDBe:6cu6, PDBj:6cu6
PDBsum6cu6
PubMed31649109
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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