Structure of PDB 6cpm Chain C

Receptor sequence
>6cpmC (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
SEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL
NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGQ
DCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKR
NDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLK
DCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFS
YSRYMRDKLDTLVDFPINDLDMSGCRYNLIAVSNHYGGMGGGHYTAFAKN
KDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDSSG
3D structure
PDB6cpm Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
ChainC
Resolution2.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D548 Q614 D269 Q335
BS02 CA C I546 E598 I267 E319
BS03 ZN C C448 C451 C499 C502 C169 C172 C220 C223
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6cpm, PDBe:6cpm, PDBj:6cpm
PDBsum6cpm
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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