Structure of PDB 6cha Chain C

Receptor sequence
>6chaC (length=97) Species: 9913 (Bos taurus) [Search protein sequence]
ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGP
LVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN
3D structure
PDB6cha Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution.
ChainC
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) M44 G45 D46 S47 G48
Enzyme Commision number 3.4.21.1: chymotrypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C A206 W207 A58 W59
BS02 PBA C S190 C191 S195 V213 W215 S42 C43 S47 V65 W67 MOAD: Ki=40uM
PDBbind-CN: -logKd/Ki=4.40,Ki=40uM
BindingDB: Ki=40nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6cha, PDBe:6cha, PDBj:6cha
PDBsum6cha
PubMed3584139
UniProtP00766|CTRA_BOVIN Chymotrypsinogen A

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