Structure of PDB 6cg1 Chain C

Receptor sequence
>6cg1C (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
ARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDD
IDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRY
FEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE
SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPP
EHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQE
AGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKISM
DVFVRKFQPERYKLWKAGKTVIDHTLPTPEAAEFL
3D structure
PDB6cg1 Structure-based design and discovery of potent and selective KDM5 inhibitors.
ChainC
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C234 H240 C306 C308 C221 H227 C293 C295
BS02 QC1 C Y132 A134 F185 H188 K206 W208 H276 Y119 A121 F172 H175 K193 W195 H263
External links
PDB RCSB:6cg1, PDBe:6cg1, PDBj:6cg1
PDBsum6cg1
PubMed29627262
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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