Structure of PDB 6cep Chain C

Receptor sequence
>6cepC (length=331) Species: 9823 (Sus scrofa) [Search protein sequence]
ATLKEKLIAPVAEEETTIPNNKITVVGVGQVGMACAISILGKSLTDELAL
VDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQ
QEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKL
SGLPKHRVIGSGCNLDSARFRYLMAEKLGVHPSSCHGWILGEHGDSSVAV
WSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNW
AIGLSVADLIESMLKNLSRIHPVSTMVQGMYGIENEVFLSLPCVLNARGL
TSVINQKLKDDEVAQLKNSADTLWGIQKDLK
3D structure
PDB6cep Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 N138 H193 T248 I252 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 N138 H193 T248 I252
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cep, PDBe:6cep, PDBj:6cep
PDBsum6cep
PubMed30151092
UniProtP00336|LDHB_PIG L-lactate dehydrogenase B chain (Gene Name=LDHB)

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