Structure of PDB 6cce Chain C

Receptor sequence
>6cceC (length=1095) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGE
ENPVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTY
AAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQL
VRSPGVYFDETIDKSTEKTLHSVKVIPGRGAWLEFVRIDRKRRQPVTVLL
KALEQIVERFGFSEIMMGTLEKDTTSGTDEALLDIYRKLRPGEPPTKESA
QTLLENLFFKEKRYDLARVGRYKVNKKLTLTEEDVVATIEYLVRLHEGQT
SMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQIRVGLSRMERVVRER
MTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKR
RLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVY
ARVNPFGFIETPYRKVENGVVTDQIDYLTADEEDRHVVAQANSPTDENGR
FTEDRVMVRKKGGEVEFVSADQVDYMDVSPRQMVSVATAMIPFLEHDDAN
RALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVADKTGVIEEV
SADYITVMADDGTRQSYRLRKFARSNHGTCANQRPIVDAGQRVEAGQVIA
DGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIE
EHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILV
GKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVF
SREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVED
MPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKAGWNIDVAAGVP
DWASKLPEELYSAPADSTVATPVFDGAQEGELAGLLGSTLPNRDGEVMVD
ADGKSTLFDGRSGEPFPYPVTVGYMYILKLHHLVDDKIHARSTGPYSMIT
QQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVY
EAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMR
3D structure
PDB6cce Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
ChainC
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L266 G275 E276 P277 P278 L233 G242 E243 P244 P245
BS02 KNG C R164 T424 S425 Q426 S428 Q429 F430 D432 R445 S447 L449 R456 I488 R604 R144 T380 S381 Q382 S384 Q385 F386 D388 R401 S403 L405 R412 I444 R560
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cce, PDBe:6cce, PDBj:6cce
PDBsum6cce
PubMed30297823
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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